Home > Psoriatic Arthritis > Psoriatic Arthritis – How does methotrexate work?

Psoriatic Arthritis – How does methotrexate work?

Methotrexate is similar to a normal molecule called folinic acid, which is required for copying DNA. The drug prevents cells from making and repairing DNA

http://info.cancerresearchuk.org/news/archive/pressreleases/2009/august/methotrexate-inherited-cancer

I found this definition on the Cancer Research UK website and I thought it was a good explanation.  Methotrexate was originally developed to treat cancer.  High doses (5omg or more) are used to treat some times of cancer ( e.g. leukaemia).  Lower doses (10-20mgs) are used to treat some types of inflammatory arthritis, like rheumatoid arthritis or psoriatic arthritis.  You can’t take this drug if you are pregnant (or trying to get pregnant) as it could damage your unborn baby.  This also applies to men, men shouldn’t take methotrexate if they are trying to father a child.

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