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Immune regulation in psoriasis and psoriatic arthritis – recent developments

October 10, 2009 2 comments

Nice to know that some psoriatic arthritis research is being done in Scotland

http://www.gla.ac.uk/departments/immunology/researchgroups/iainmcinnes/selectedpublications/#d.en.67680

Here is another paper that looks interesting but I don’t have access to….

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T75-4PRRG5M-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c84cf3c10ecf57834e47caa55c8ed971

Axel J. HueberCorresponding Author Contact Information, a, E-mail The Corresponding Author and Iain B. McInnesa

aDivision of Immunology, Infection and Inflammation, 120 University Place, Glasgow G128QQ, United Kingdom

Received 21 August 2007;

accepted 30 August 2007.

Available online 25 September 2007.

Abstract

Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal–immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have led to the introduction of novel therapeutics providing the ultimate proof of concept in defining the role of these targets in the pathogenetic response. The pro-inflammatory cytokines TNF, IL-12/IL-23 and a variety of co-stimulator molecules have all been identified as critical factors in disease progression. In this short review we summarise key recent developments in understanding of the role of cytokines, T cells, B cells in psoriatic disease pathogenesis. We also describe the pathways that are believed to link such inflammatory pathways to articular matrix dysregulation.

Keywords: Psoriasis; Arthritis; Cytokine; Lymphocyte; Immune regulation

Categories: psoriatic Tags: , ,