Posts Tagged ‘methotrexate’

Things I can do on methotrexate…

Last year I started taking methotrexate.  The first 4 months were rough.  The first 2 months were really rough.  On the plus side after about 6 months I started noticing some changes, and gradually, bit by bit things have started getting better.

1 I have more energy, I no longer feel like I have to lie down at 4pm because I physically can’t keep going.

2 I can think better – thinking is easier, faster less like dragging myself through fog.

3 I have more movement in my joints, I can…

  • turn over in bed, automatically and without thinking about it
  • move my fingers, type and play the flute (not brilliantly but a damn site better than I was)
  • shampoo my hair and wring the water out of it
  • wash my hands without pain
  • stand for long enough to cook tea and wash the dishes!
  • lift a kettle full of boiling water
  • lift something in and out of the oven, without a meticulous plan
  • pick stuff off the floor
  • get down to the floor and back up again
  • stand for long enough to clean my teeth
  • walk on uneven ground or ice and correct my balance
  • run a few steps (if I need to! useful for catching falling children…)
  • get out of bed in the morning and stand up straight

4 Doing my job no longer feels like a herculean effort demanding every last ounce of my strength.

So the down sides.

1 I felt exhausted, wiped out, and breathless for months, although that has passed

2 Nausea, I take it weekly, I still feel sick for 2-3 days

3 I don’t sleep well the night I take it

4 I feel wiped out 2-3 days after taking it

5 The regular blood tests make me feel like a “sick person”

6 My blood counts vary, I’m worried I’ll have to stop taking it.

7 Remembering to refill the prescription is a pain (and the “high risk” sticker never makes me feel good).

8 Every time I get any sort of infection I worry I won’t be able to fight it off.

9 Every time my kids/family/friends get sick I worry I’ll get what they’ve got .

10 What (when?) will it stop working for me?



Psoriatic Arthritis – How does methotrexate work?

Methotrexate is similar to a normal molecule called folinic acid, which is required for copying DNA. The drug prevents cells from making and repairing DNA

I found this definition on the Cancer Research UK website and I thought it was a good explanation.  Methotrexate was originally developed to treat cancer.  High doses (5omg or more) are used to treat some times of cancer ( e.g. leukaemia).  Lower doses (10-20mgs) are used to treat some types of inflammatory arthritis, like rheumatoid arthritis or psoriatic arthritis.  You can’t take this drug if you are pregnant (or trying to get pregnant) as it could damage your unborn baby.  This also applies to men, men shouldn’t take methotrexate if they are trying to father a child.

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